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SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation
The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits retroviruses, DNA viruses and long interspersed element 1 (LINE-1). Given that in dividing cells, SAMHD1 loses its antiviral function yet still potently restricts LINE-1, we propose that, instead of blocking viral DNA synthesis by v...
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| Izdano u: | PLoS Genet |
|---|---|
| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4489885/ https://ncbi.nlm.nih.gov/pubmed/26134849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005367 |
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