Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells

Synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9(11)-dien-28-oate (CDDO-Me) has been shown as a promising agent against ovarian cancer. However, the underlying mechanism is not well understood. Here, we demonstrate that CDDO-Me directly interacts with Hsp90 in cells by cellular thermal s...

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Udgivet i:PLoS One
Main Authors: Qin, Dong-Jun, Tang, Cai-Xia, Yang, Li, Lei, Hu, Wei, Wei, Wang, Ying-Ying, Ma, Chun-Min, Gao, Feng-Hou, Xu, Han-Zhang, Wu, Ying-Li
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489813/
https://ncbi.nlm.nih.gov/pubmed/26134508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132337
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