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Characterization of permeability, stability and anti-HIV-1 activity of decitabine and gemcitabine divalerate prodrugs

BACKGROUND: Over 25 drugs have been approved for the treatment of HIV-1 replication. All but one of these drugs is delivered as an oral medication. Previous studies have demonstrated that two drugs, decitabine and gemcitabine, have potent anti-HIV-1 activities and can work together in synergy to red...

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Bibliographic Details
Published in:Antivir Chem Chemother
Main Authors: Clouser, Christine L, Bonnac, Laurent, Mansky, Louis M, Patterson, Steven E
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489529/
https://ncbi.nlm.nih.gov/pubmed/23994876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3851/IMP2682
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