Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase.

Eitemau Tebyg

• Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation.
  gan: Patriotis, C, et al.
  Cyhoeddwyd: (1993)
• Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase.
  gan: Williams, N G, et al.
  Cyhoeddwyd: (1993)
• Targeting the Mitogen-Activated Protein Kinase RAS-RAF Signaling Pathway in Cancer Therapy
  gan: Santarpia, Libero, et al.
  Cyhoeddwyd: (2012)
• Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase
  gan: Terai, Kenta, et al.
  Cyhoeddwyd: (2005)
• Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation.
  gan: King, W G, et al.
  Cyhoeddwyd: (1997)