Methotrexate Is a JAK/STAT Pathway Inhibitor

BACKGROUND: The JAK/STAT pathway transduces signals from multiple cytokines and controls haematopoiesis, immunity and inflammation. In addition, pathological activation is seen in multiple malignancies including the myeloproliferative neoplasms (MPNs). Given this, drug development efforts have targe...

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Publicado en:PLoS One
Autores principales: Thomas, Sally, Fisher, Katherine H., Snowden, John A., Danson, Sarah J., Brown, Stephen, Zeidler, Martin P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489434/
https://ncbi.nlm.nih.gov/pubmed/26131691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130078
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