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Methotrexate Is a JAK/STAT Pathway Inhibitor
BACKGROUND: The JAK/STAT pathway transduces signals from multiple cytokines and controls haematopoiesis, immunity and inflammation. In addition, pathological activation is seen in multiple malignancies including the myeloproliferative neoplasms (MPNs). Given this, drug development efforts have targe...
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| Publicado en: | PLoS One |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4489434/ https://ncbi.nlm.nih.gov/pubmed/26131691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130078 |
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