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Methotrexate Is a JAK/STAT Pathway Inhibitor
BACKGROUND: The JAK/STAT pathway transduces signals from multiple cytokines and controls haematopoiesis, immunity and inflammation. In addition, pathological activation is seen in multiple malignancies including the myeloproliferative neoplasms (MPNs). Given this, drug development efforts have targe...
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| Опубликовано в: : | PLoS One |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4489434/ https://ncbi.nlm.nih.gov/pubmed/26131691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130078 |
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