Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance

OBJECTIVES: Angiopoietin-like protein 2 (ANGPTL2), a recently identified pro-inflammatory cytokine, is mainly secreted from the adipose tissue. This study aimed to explore the role of ANGPTL2 in adipose tissue inflammation and macrophage activation in a mouse model of diabetes. METHODOLOGY/PRINCIPAL...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sasaki, Yusuke, Ohta, Masayuki, Desai, Dhruv, Figueiredo, Jose-Luiz, Whelan, Mary C., Sugano, Tomohiro, Yamabi, Masaki, Yano, Wataru, Faits, Tyler, Yabusaki, Katsumi, Zhang, Hengmin, Mlynarchik, Andrew K., Inoue, Keisuke, Mizuno, Ken, Aikawa, Masanori
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489192/
https://ncbi.nlm.nih.gov/pubmed/26132105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131176
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