Identification of a New Functional Domain in Angiopoietin-like 3 (ANGPTL3) and Angiopoietin-like 4 (ANGPTL4) Involved in Binding and Inhibition of Lipoprotein Lipase (LPL)

Angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) are secreted proteins that regulate triglyceride (TG) metabolism in part by inhibiting lipoprotein lipase (LPL). Recently, we showed that treatment of wild-type mice with monoclonal antibody (mAb) 14D12, specific for ANGPTL4, recapitula...

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Main Authors: Lee, E-Chiang, Desai, Urvi, Gololobov, Gennady, Hong, Seokjoo, Feng, Xiao, Yu, Xuan-Chuan, Gay, Jason, Wilganowski, Nat, Gao, Cuihua, Du, Ling-Ling, Chen, Joan, Hu, Yi, Zhao, Sharon, Kirkpatrick, Laura, Schneider, Matthias, Zambrowicz, Brian P., Landes, Greg, Powell, David R., Sonnenburg, William K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679475/
https://ncbi.nlm.nih.gov/pubmed/19318355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807899200
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