Effects of Integrating and Non-Integrating Reprogramming Methods on Copy Number Variation and Genomic Stability of Human Induced Pluripotent Stem Cells

Human-induced pluripotent stem cells (iPSCs) are derived from differentiated somatic cells using defined factors and provide a renewable source of autologous cells for cell therapy. Many reprogramming methods have been employed to generate human iPSCs, including the use of integrating vectors and no...

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Bibliographic Details
Published in:PLoS One
Main Authors: Kang, Xiangjin, Yu, Qian, Huang, Yuling, Song, Bing, Chen, Yaoyong, Gao, Xingcheng, He, Wenyin, Sun, Xiaofang, Fan, Yong
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488894/
https://ncbi.nlm.nih.gov/pubmed/26131765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131128
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