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Microsatellite Instability Use in Mismatch Repair Gene Sequence Variant Classification

Inherited mutations in the DNA mismatch repair genes (MMR) can cause MMR deficiency and increased susceptibility to colorectal and endometrial cancer. Microsatellite instability (MSI) is the defining molecular signature of MMR deficiency. The clinical classification of identified MMR gene sequence v...

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Bibliografski detalji
Izdano u:Genes (Basel)
Glavni autori: Thompson, Bryony A., Spurdle, Amanda B.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488658/
https://ncbi.nlm.nih.gov/pubmed/25831438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes6020150
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