HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats

OBJECTIVES: HLA-B27 is a common genetic risk factor for the development of Spondyloarthritides (SpA). HLA-B27 can misfold to form cell-surface heavy chain homodimers (B27(2)) and induce pro-inflammatory responses that may lead to SpA pathogenesis. The presence of B27(2) can be detected on leukocytes...

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Publicado en:PLoS One
Main Authors: Marroquin Belaunzaran, Osiris, Kleber, Sascha, Schauer, Stefan, Hausmann, Martin, Nicholls, Flora, Van den Broek, Maries, Payeli, Sravan, Ciurea, Adrian, Milling, Simon, Stenner, Frank, Shaw, Jackie, Kollnberger, Simon, Bowness, Paul, Petrausch, Ulf, Renner, Christoph
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488392/
https://ncbi.nlm.nih.gov/pubmed/26125554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130811
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