HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats

OBJECTIVES: HLA-B27 is a common genetic risk factor for the development of Spondyloarthritides (SpA). HLA-B27 can misfold to form cell-surface heavy chain homodimers (B27(2)) and induce pro-inflammatory responses that may lead to SpA pathogenesis. The presence of B27(2) can be detected on leukocytes...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Marroquin Belaunzaran, Osiris, Kleber, Sascha, Schauer, Stefan, Hausmann, Martin, Nicholls, Flora, Van den Broek, Maries, Payeli, Sravan, Ciurea, Adrian, Milling, Simon, Stenner, Frank, Shaw, Jackie, Kollnberger, Simon, Bowness, Paul, Petrausch, Ulf, Renner, Christoph
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488392/
https://ncbi.nlm.nih.gov/pubmed/26125554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130811
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