HLA-B27 Homodimers and Free H Chains Are Stronger Ligands for Leukocyte Ig-like Receptor B2 than Classical HLA Class 1

Possession of HLA-B27 (B27), strongly predisposes to the development of spondyloarthritis. B27 forms classical heterotrimeric complexes with beta-2-microglobulin (β2m) and peptide, and (β2m–free) free H chain (FHC) forms including B27 dimers (termed B27(2)) at the cell surface. In this study we char...

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Detalhes bibliográficos
Main Authors: Giles, Joanna, Shaw, Jackie, Piper, Christopher, Wong-Baeza, Isabel, McHugh, Kirsty, Ridley, Anna, Li, Demin, Lenart, Izabela, Antoniou, Antony N., DiGleria, Katilin, Kuroki, Kimiko, Maenaka, Katsumi, Bowness, Paul, Kollnberger, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622243/
https://ncbi.nlm.nih.gov/pubmed/22593621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102711
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