Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers

Somatic mutations in the nuclear genome are required for tumor formation, but the functional consequences of somatic mitochondrial DNA (mtDNA) mutations are less understood. Here we identify somatic mtDNA mutations across 527 tumors and 14 cancer types, using an approach that takes advantage of evid...

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Dettagli Bibliografici
Pubblicato in:PLoS Genet
Autori principali: Stewart, James B., Alaei-Mahabadi, Babak, Sabarinathan, Radhakrishnan, Samuelsson, Tore, Gorodkin, Jan, Gustafsson, Claes M., Larsson, Erik
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488357/
https://ncbi.nlm.nih.gov/pubmed/26125550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005333
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