Reverse genetic screening reveals poor correlation between Morpholino-induced and mutant phenotypes in zebrafish

The widespread availability of programmable site-specific nucleases now enables targeted gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate zebrafish lines bearing individual mutations in more than twenty genes. We found that mutations in only a small pro...

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Udgivet i:Dev Cell
Main Authors: Kok, F. O., Shin, M., Ni, C-W., Gupta, A., Grosse, A. S., van Impel, A., Kirchmaier, B. C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S. A., Lawson, N. D.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487878/
https://ncbi.nlm.nih.gov/pubmed/25533206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.11.018
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