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Reverse genetic screening reveals poor correlation between Morpholino-induced and mutant phenotypes in zebrafish
The widespread availability of programmable site-specific nucleases now enables targeted gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate zebrafish lines bearing individual mutations in more than twenty genes. We found that mutations in only a small pro...
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| Publicado no: | Dev Cell |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4487878/ https://ncbi.nlm.nih.gov/pubmed/25533206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.11.018 |
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