Osteopontin Neutralization Abrogates the Liver Progenitor Cell Response and Fibrogenesis in Mice

BACKGROUND: Chronic liver injury triggers a progenitor-cell repair-response, and liver fibrosis occurs when repair becomes de-regulated. Previously, we reported that reactivation of the Hedgehog (Hh) pathway promotes fibrogenic liver-repair. Osteopontin (OPN) is a Hh-target, and a cytokine that is h...

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Publicado en:Gut
Autores principales: Coombes, J, Swiderska-Syn, M, Dollé, L, Reid, D, Eksteen, B, Claridge, L, Briones-Orta, MA, Shetty, S, Oo, YH, Riva, A, Chokshi, S, Papa, S, Mi, Z, Kuo, PC, Williams, R, Canbay, A, Adams, DH, Diehl, AM, van Grunsven, LA, Choi, SS, Syn, WK
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487727/
https://ncbi.nlm.nih.gov/pubmed/24902765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2013-306484
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