Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis

INTRODUCTION: Liver fibrosis develops when hepatic stellate cells (HSC) are activated into collagen-producing myofibroblasts. In non-alcoholic steatohepatitis (NASH), the adipokine leptin is upregulated, and promotes liver fibrosis by directly activating HSC via the hedgehog pathway. We reported tha...

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Publicado no:Biochim Biophys Acta
Main Authors: Coombes, Jason D., Choi, Steve S., Swiderska-Syn, Marzena, Manka, Paul P., Reid, Danielle, Palma, Elena, Briones-Orta, Marco A., Xie, Guanhua, Younis, Rasha, Kitamura, Naoto, Peruta, Marco della, Bitencourt, Shanna, Dollé, Laurent, Oo, Ye Htun, Mi, Zhiyong, Kuo, Paul C., Williams, Roger, Chokshi, Shilpa, Canbay, Ali, Claridge, Lee C., Eksteen, Bertus, Diehl, Anna Mae, Syn, Wing-Kin
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756594/
https://ncbi.nlm.nih.gov/pubmed/26529285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2015.10.028
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