Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis

INTRODUCTION: Liver fibrosis develops when hepatic stellate cells (HSC) are activated into collagen-producing myofibroblasts. In non-alcoholic steatohepatitis (NASH), the adipokine leptin is upregulated, and promotes liver fibrosis by directly activating HSC via the hedgehog pathway. We reported tha...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochim Biophys Acta
Prif Awduron: Coombes, Jason D., Choi, Steve S., Swiderska-Syn, Marzena, Manka, Paul P., Reid, Danielle, Palma, Elena, Briones-Orta, Marco A., Xie, Guanhua, Younis, Rasha, Kitamura, Naoto, Peruta, Marco della, Bitencourt, Shanna, Dollé, Laurent, Oo, Ye Htun, Mi, Zhiyong, Kuo, Paul C., Williams, Roger, Chokshi, Shilpa, Canbay, Ali, Claridge, Lee C., Eksteen, Bertus, Diehl, Anna Mae, Syn, Wing-Kin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756594/
https://ncbi.nlm.nih.gov/pubmed/26529285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2015.10.028
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