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Highly homologous proteins exert opposite biological activities by using different interaction interfaces

We present a possible molecular basis for the opposite activity of two homologues proteins that bind similar ligands and show that this is achieved by fine-tuning of the interaction interface. The highly homologous ASPP proteins have opposite roles in regulating apoptosis: ASPP2 induces apoptosis wh...

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Foilsithe in:Sci Rep
Main Authors: Iosub Amir, Anat, van Rosmalen, Martijn, Mayer, Guy, Lebendiker, Mario, Danieli, Tsafi, Friedler, Assaf
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2015
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486954/
https://ncbi.nlm.nih.gov/pubmed/26130271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11629
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