Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2

We have characterized the molecular basis of the interaction between ASPP2 and Bcl-2, which are key proteins in the apoptotic pathway. The C-terminal ankyrin repeats and SH3 domain of ASPP2 (ASPP2(Ank-SH3)) mediate its interactions with the antiapoptotic protein Bcl-2. We used biophysical and comput...

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Autori principali: Katz, Chen, Benyamini, Hadar, Rotem, Shahar, Lebendiker, Mario, Danieli, Tsafi, Iosub, Anat, Refaely, Hadar, Dines, Monica, Bronner, Vered, Bravman, Tsafrir, Shalev, Deborah E., Rüdiger, Stefan, Friedler, Assaf
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527902/
https://ncbi.nlm.nih.gov/pubmed/18719108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711269105
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