The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells

Suppression of apoptosis is a key Hallmark of cancer cells, and reactivation of apoptosis is a major avenue for cancer therapy. We reveal an interaction between the two anti-apoptotic proteins iASPP and NAF-1, which are overexpressed in many types of cancer cells and tumors. iASPP is an inhibitory m...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Iosub-Amir, Anat, Bai, Fang, Sohn, Yang-Sung, Song, Luhua, Tamir, Sagi, Marjault, Henri-Baptiste, Mayer, Guy, Karmi, Ola, Jennings, Patricia A., Mittler, Ron, Onuchic, José N., Friedler, Assaf, Nechushtai, Rachel
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349067/
https://ncbi.nlm.nih.gov/pubmed/30774867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc03390k
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