Age-related increases in amyloid beta and membrane attack complex: evidence of inflammasome activation in the rodent eye

BACKGROUND: The membrane attack complex (MAC) is a key player in the pathogenesis of age-related macular degeneration (AMD) and is a putative activator of the NLRP3 inflammasome. Amyloid beta (Aβ), a component of drusen deposits, has also been implicated in inflammasome activation by our work and th...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Zhao, Tom, Gao, Jiangyuan, Van, Jenifer, To, Eleanor, Wang, Aikun, Cao, Sijia, Cui, Jing Z., Guo, Jian-Ping, Lee, Moonhee, McGeer, Patrick L., Matsubara, Joanne A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486438/
https://ncbi.nlm.nih.gov/pubmed/26104676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0337-1
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados