Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye

BACKGROUND: Age-related macular degeneration (AMD) is a devastating eye disease causing irreversible vision loss in the elderly. Retinal pigment epithelium (RPE), the primary cell type that is afflicted in AMD, undergoes programmed cell death in the late stages of the disease. However, the exact mec...

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Bibliografiska uppgifter
I publikationen:J Neuroinflammation
Huvudupphovsmän: Gao, Jiangyuan, Cui, Jing Z., To, Eleanor, Cao, Sijia, Matsubara, Joanne A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2018
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766992/
https://ncbi.nlm.nih.gov/pubmed/29329580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1062-3
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