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Models in biology: lessons from modeling regulation of the eukaryotic cell cycle

In this essay we illustrate some general principles of mathematical modeling in biology by our experiences in studying the molecular regulatory network underlying eukaryotic cell division. We discuss how and why the models moved from simple, parsimonious cartoons to more complex, detailed mechanisms...

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Detalhes bibliográficos
Publicado no:BMC Biol
Main Authors: Tyson, John J., Novák, Béla
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486427/
https://ncbi.nlm.nih.gov/pubmed/26129844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-015-0158-9
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