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Models in biology: lessons from modeling regulation of the eukaryotic cell cycle

In this essay we illustrate some general principles of mathematical modeling in biology by our experiences in studying the molecular regulatory network underlying eukaryotic cell division. We discuss how and why the models moved from simple, parsimonious cartoons to more complex, detailed mechanisms...

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Bibliographic Details
Published in:BMC Biol
Main Authors: Tyson, John J., Novák, Béla
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486427/
https://ncbi.nlm.nih.gov/pubmed/26129844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-015-0158-9
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