GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis

Inactivation of Gli3, a key component of Hedgehog signaling in vertebrates, results in formation of additional digits (polydactyly) during limb bud development. The analysis of mouse embryos constitutively lacking Gli3 has revealed the essential GLI3 functions in specifying the anteroposterior (AP)...

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Udgivet i:Dev Cell
Main Authors: Lopez-Rios, Javier, Speziale, Dario, Robay, Dimitri, Scotti, Martina, Osterwalder, Marco, Nusspaumer, Gretel, Galli, Antonella, Holländer, Georg A., Kmita, Marie, Zeller, Rolf
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486391/
https://ncbi.nlm.nih.gov/pubmed/22465667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.01.006
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