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Stable Isotope Resolved Metabolomics Analysis of Ribonucleotide and RNA Metabolism in Human Lung Cancer Cells

We have developed a simple NMR-based method to determine the turnover of nucleotides and incorporation into RNA by stable isotope resolved metabolomics (SIRM) in A549 lung cancer cells. This method requires no chemical degradation of the nucleotides or chromatography. During cell growth, the free ri...

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Dettagli Bibliografici
Pubblicato in:Metabolomics
Autori principali: Fan, Teresa W-M., Tan, Jinlian, McKinney, Martin M., Lane, Andrew N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486296/
https://ncbi.nlm.nih.gov/pubmed/26146495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11306-011-0337-9
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