Population Pharmacokinetics and Pharmacodynamics of Linagliptin in Patients with Type 2 Diabetes Mellitus

BACKGROUND AND OBJECTIVES: Linagliptin is a dipeptidyl peptidase (DPP)-4 inhibitor, used to treat type 2 diabetes mellitus (T2DM). Population pharmacokinetic and pharmacodynamic analyses were performed to characterize the impact of clinically relevant intrinsic/extrinsic factors (covariates) on lina...

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Bibliographic Details
Published in:Clin Pharmacokinet
Main Authors: Retlich, Silke, Duval, Vincent, Graefe-Mody, Ulrike, Friedrich, Christian, Patel, Sanjay, Jaehde, Ulrich, Staab, Alexander
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2015
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Original Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486092/
https://ncbi.nlm.nih.gov/pubmed/25637172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-014-0232-4
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