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Molecular determinants involved in activation of caspase 7
During apoptosis, initiator caspases (8, 9, and 10) activate downstream executioner caspases (3, 6, and 7) by cleaving the interdomain connector (IDC) at two sites. Here, we demonstrate that both activation sites, site 1 and site 2, of caspase 7 are suboptimal for activation by initiator caspases 8...
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| Veröffentlicht in: | Biosci Rep |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4485920/ https://ncbi.nlm.nih.gov/pubmed/20942802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20100111 |
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