Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

Pancreatic α cells are exposed to metabolic stress during the evolution of type 2 diabetes (T2D), but it remains unclear whether this affects their survival. We used electron microscopy to search for markers of apoptosis and endoplasmic reticulum (ER) stress in α and β cells in islets from T2D or no...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Marroqui, Laura, Masini, Matilde, Merino, Beatriz, Grieco, Fabio A., Millard, Isabelle, Dubois, Christine, Quesada, Ivan, Marchetti, Piero, Cnop, Miriam, Eizirik, Decio L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485913/
https://ncbi.nlm.nih.gov/pubmed/26137583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.03.012
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