Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression

Inhibition of JAK1 or JAK2 in human tumor cells was previously shown to increase susceptibility of these cells to NK cell lysis. In the present study, we examined the cellular mechanisms that mediate this effect in hematopoietic tumor cell lines and primary tumor cells. Incubation of tumor cells wit...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Bellucci, Roberto, Martin, Allison, Bommarito, Davide, Wang, Kathy, Hansen, Steen H, Freeman, Gordon J, Ritz, Jerome
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485824/
https://ncbi.nlm.nih.gov/pubmed/26155422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1008824
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