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Deciphering the genetic evolution of T-cell resistance in melanoma
T–cell-based immunotherapy of melanoma becomes ineffective when β2m-deficient tumor cells of a human leukocyte antigen (HLA) class I-negative phenotype grow out. We demonstrated that an early-acquired chromosomal deletion and subsequent inactivating gene mutation lead to β2m deficiency, suggesting t...
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| Pubblicato in: | Oncoimmunology |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4485751/ https://ncbi.nlm.nih.gov/pubmed/26155406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1005510 |
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