Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies

We have developed a highly versatile platform for the systematic retrieval of T-cell receptors (TCRs) from single-antigen-reactive T cells and for characterization of their function and specificity. This approach enables rapid extraction of multiple TCRs from repertoires in individuals and not only...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Omokoko, Tana, Simon, Petra, Türeci, Özlem, Sahin, Ugur
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485745/
https://ncbi.nlm.nih.gov/pubmed/26140230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1005523
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