Trbp regulates heart function through miRNA-mediated Sox6 repression

Cardiomyopathy is associated with altered expression of genes encoding contractile proteins. Here we show that Trbp (Tarbp2), an RNA binding protein, is required for normal heart function. Cardiac-specific inactivation of Trbp (Trbp(cKO)) caused progressive cardiomyopathy and lethal heart failure. T...

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Udgivet i:Nat Genet
Main Authors: Ding, Jian, Chen, Jinghai, Wang, Yanqun, Kataoka, Masaharu, Ma, Lixin, Zhou, Pingzhu, Hu, Xiaoyun, Lin, Zhiqiang, Nie, Mao, Deng, Zhong-Liang, Pu, William T, Wang, Da-Zhi
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485565/
https://ncbi.nlm.nih.gov/pubmed/26029872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3324
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