Trbp regulates heart function through miRNA-mediated Sox6 repression

Cardiomyopathy is associated with altered expression of genes encoding contractile proteins. Here we show that Trbp (Tarbp2), an RNA binding protein, is required for normal heart function. Cardiac-specific inactivation of Trbp (Trbp(cKO)) caused progressive cardiomyopathy and lethal heart failure. T...

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Publié dans:Nat Genet
Auteurs principaux: Ding, Jian, Chen, Jinghai, Wang, Yanqun, Kataoka, Masaharu, Ma, Lixin, Zhou, Pingzhu, Hu, Xiaoyun, Lin, Zhiqiang, Nie, Mao, Deng, Zhong-Liang, Pu, William T, Wang, Da-Zhi
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485565/
https://ncbi.nlm.nih.gov/pubmed/26029872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3324
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