Trbp regulates heart function through miRNA-mediated Sox6 repression

Cardiomyopathy is associated with altered expression of genes encoding contractile proteins. Here we show that Trbp (Tarbp2), an RNA binding protein, is required for normal heart function. Cardiac-specific inactivation of Trbp (Trbp(cKO)) caused progressive cardiomyopathy and lethal heart failure. T...

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Publicado no:Nat Genet
Main Authors: Ding, Jian, Chen, Jinghai, Wang, Yanqun, Kataoka, Masaharu, Ma, Lixin, Zhou, Pingzhu, Hu, Xiaoyun, Lin, Zhiqiang, Nie, Mao, Deng, Zhong-Liang, Pu, William T, Wang, Da-Zhi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485565/
https://ncbi.nlm.nih.gov/pubmed/26029872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3324
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