Trbp regulates heart function through miRNA-mediated Sox6 repression

Cardiomyopathy is associated with altered expression of genes encoding contractile proteins. Here we show that Trbp (Tarbp2), an RNA binding protein, is required for normal heart function. Cardiac-specific inactivation of Trbp (Trbp(cKO)) caused progressive cardiomyopathy and lethal heart failure. T...

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Detaylı Bibliyografya
Yayımlandı:Nat Genet
Asıl Yazarlar: Ding, Jian, Chen, Jinghai, Wang, Yanqun, Kataoka, Masaharu, Ma, Lixin, Zhou, Pingzhu, Hu, Xiaoyun, Lin, Zhiqiang, Nie, Mao, Deng, Zhong-Liang, Pu, William T, Wang, Da-Zhi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485565/
https://ncbi.nlm.nih.gov/pubmed/26029872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3324
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