Genome-wide patterns and properties of de novo mutations in humans

Mutations create variation in the population, fuel evolution, and cause genetic diseases. Current knowledge about de novo mutations is incomplete and mostly indirect (1–10). Here, we analyze 11,020 de novo mutations from whole-genomes of 250 families. We show that de novo mutations in offspring of o...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Genet
Main Authors: Francioli, Laurent C., Polak, Paz P., Koren, Amnon, Menelaou, Androniki, Chun, Sung, Renkens, Ivo, van Duijn, Cornelia M., Swertz, Morris, Wijmenga, Cisca, van Ommen, Gertjan, Slagboom, P. Eline, Boomsma, Dorret I., Ye, Kai, Guryev, Victor, Arndt, Peter F., Kloosterman, Wigard P., de Bakker, Paul I. W., Sunyaev, Shamil R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485564/
https://ncbi.nlm.nih.gov/pubmed/25985141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3292
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker