Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

Although previous studies have documented a bottleneck in the transmission of mtDNA genomes from mothers to offspring, several aspects remain unclear, including the size and nature of the bottleneck. Here, we analyze the dynamics of mtDNA heteroplasmy transmission in the Genomes of the Netherlands (...

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Veröffentlicht in:Genome Res
Hauptverfasser: Li, Mingkun, Rothwell, Rebecca, Vermaat, Martijn, Wachsmuth, Manja, Schröder, Roland, Laros, Jeroen F.J., van Oven, Mannis, de Bakker, Paul I.W., Bovenberg, Jasper A., van Duijn, Cornelia M., van Ommen, Gert-Jan B., Slagboom, P. Eline, Swertz, Morris A., Wijmenga, Cisca, Kayser, Manfred, Boomsma, Dorret I., Zöllner, Sebastian, de Knijff, Peter, Stoneking, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817766/
https://ncbi.nlm.nih.gov/pubmed/26916109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.203216.115
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