Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

Although previous studies have documented a bottleneck in the transmission of mtDNA genomes from mothers to offspring, several aspects remain unclear, including the size and nature of the bottleneck. Here, we analyze the dynamics of mtDNA heteroplasmy transmission in the Genomes of the Netherlands (...

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Detalles Bibliográficos
Publicado en:Genome Res
Main Authors: Li, Mingkun, Rothwell, Rebecca, Vermaat, Martijn, Wachsmuth, Manja, Schröder, Roland, Laros, Jeroen F.J., van Oven, Mannis, de Bakker, Paul I.W., Bovenberg, Jasper A., van Duijn, Cornelia M., van Ommen, Gert-Jan B., Slagboom, P. Eline, Swertz, Morris A., Wijmenga, Cisca, Kayser, Manfred, Boomsma, Dorret I., Zöllner, Sebastian, de Knijff, Peter, Stoneking, Mark
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817766/
https://ncbi.nlm.nih.gov/pubmed/26916109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.203216.115
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