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CaMKII inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions

BACKGROUND: Aberrant calcium signaling is considered as one of the key mechanisms contributing to arrhythmias, especially in the context of heart failure. In human heart failure, there is significant down-regulation of the sarcoplasmic reticulum protein junctin and junctin deficiency in mice is asso...

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Podrobná bibliografie
Vydáno v:Heart Rhythm
Hlavní autoři: Tzimas, Christos, Terrovitis, John, Lehnart, Stephan E., Kranias, Evangelia G., Sanoudou, Despina
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485547/
https://ncbi.nlm.nih.gov/pubmed/25814413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2015.03.043
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