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Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1

Forkhead box P3 (FOXP3)-positive Treg cells are crucial for maintaining immune homeostasis. FOXP3 cooperates with its binding partners to elicit Treg cells’ signature and function, but the molecular mechanisms underlying the modulation of the FOXP3 complex remain unclear. Here we report that Deleted...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Gao, Yayi, Tang, Jiayou, Chen, Weiqian, Li, Qiang, Nie, Jia, Lin, Fang, Wu, Qingsi, Chen, Zuojia, Gao, Zhimei, Fan, Huimin, Tsun, Andy, Shen, Jijia, Chen, Guihua, Liu, Zhongmin, Lou, Zhenkun, Olsen, Nancy J., Zheng, Song Guo, Li, Bin
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485127/
https://ncbi.nlm.nih.gov/pubmed/26060310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421463112
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