Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1

Over 30% of patients with amyotrophic lateral sclerosis (ALS) exhibit cognitive deficits indicative of frontotemporal dementia (FTD), suggesting a common pathogenesis for both diseases. Consistent with this hypothesis, neuronal and glial inclusions rich in TDP43, an essential RNA-binding protein, ar...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Barmada, Sami J., Ju, Shulin, Arjun, Arpana, Batarse, Anthony, Archbold, Hilary C., Peisach, Daniel, Li, Xingli, Zhang, Yuxi, Tank, Elizabeth M. H., Qiu, Haiyan, Huang, Eric J., Ringe, Dagmar, Petsko, Gregory A., Finkbeiner, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485101/
https://ncbi.nlm.nih.gov/pubmed/26056265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509744112
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