Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway

Simvastatin (SIM) is a lipid-soluble inhibitor of hydroxy-3-methylglutaryl coenzyme A reductase with multiple reported therapeutic benefits. The present study was designed to investigate the effect of pretreatment with SIM on isoproterenol (ISO)-induced cardiac hypertrophy in rats. Twenty-four male...

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Bibliografski detalji
Izdano u:Drug Des Devel Ther
Glavni autori: Al-rasheed, Nouf M, Al-Oteibi, Maha M, Al-Manee, Reem Z, Al-shareef, Sarah A, Al-Rasheed, Nawal M, Hasan, Iman H, Mohamad, Raeesa A, Mahmoud, Ayman M
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2015
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484667/
https://ncbi.nlm.nih.gov/pubmed/26150695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S86431
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