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Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway
Simvastatin (SIM) is a lipid-soluble inhibitor of hydroxy-3-methylglutaryl coenzyme A reductase with multiple reported therapeutic benefits. The present study was designed to investigate the effect of pretreatment with SIM on isoproterenol (ISO)-induced cardiac hypertrophy in rats. Twenty-four male...
Gespeichert in:
Veröffentlicht in: | Drug Des Devel Ther |
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Hauptverfasser: | , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
Dove Medical Press
2015
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4484667/ https://ncbi.nlm.nih.gov/pubmed/26150695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S86431 |
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