Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function are major determinants of endotoxin-induced insulin resistance

BACKGROUND: Endotoxin (i.e. LPS) administration induces a robust inflammatory response with accompanying cardiovascular dysfunction and insulin resistance. Overabundance of nitric oxide (NO) contributes to the vascular dysfunction. However, inflammation itself also induces insulin resistance in skel...

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Pubblicato in:Cardiovasc Diabetol
Autori principali: House, Lawrence M., Morris, Robert T., Barnes, Tammy M., Lantier, Louise, Cyphert, Travis J., McGuinness, Owen P., Otero, Yolanda F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Original Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484635/
https://ncbi.nlm.nih.gov/pubmed/25986700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-015-0223-2
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