Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment

Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the dephosphorylation of phosphatidic acid to diacylglycerol and as co-transcriptional regulators. Thus, they are...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Brohée, Laura, Demine, Stéphane, Willems, Jérome, Arnould, Thierry, Colige, Alain C., Deroanne, Christophe F.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484455/
https://ncbi.nlm.nih.gov/pubmed/25834103
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