Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin

Neuroblastoma arises from the sympathetic nervous system and accounts for 15% of childhood cancer mortality. Amplification of the oncogene N-Myc is reported to occur in more than 20% of patients. While N-Myc amplification status strongly correlates with higher tumour aggression and resistance to tre...

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Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Gangoda, Lahiru, Keerthikumar, Shivakumar, Fonseka, Pamali, Edgington, Laura E., Ang, Ching-Seng, Ozcitti, Cemil, Bogyo, Matthew, Parker, Belinda S., Mathivanan, Suresh
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2015
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484448/
https://ncbi.nlm.nih.gov/pubmed/25883214
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