Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells

Mutations in β-catenin, especially at the residues critical for its degradation, render it constitutively active. Here, we show that mutant β-catenin can be transported via extracellular vesicles (EVs) and activate Wnt signalling pathway in the recipient cells. An integrative proteogenomic analysis...

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Veröffentlicht in:J Extracell Vesicles
Hauptverfasser: Kalra, Hina, Gangoda, Lahiru, Fonseka, Pamali, Chitti, Sai V., Liem, Michael, Keerthikumar, Shivakumar, Samuel, Monisha, Boukouris, Stephanie, Al Saffar, Haidar, Collins, Christine, Adda, Christopher G., Ang, Ching-Seng, Mathivanan, Suresh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883417/
https://ncbi.nlm.nih.gov/pubmed/31819794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/20013078.2019.1690217
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