Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis

Chronic liver inflammation precedes the majority of hepatocellular carcinomas (HCC). Here, we explore the connection between chronic inflammation and DNA methylation in the liver at the late precancerous stages of HCC development in Mdr2(−/−) (Mdr2/Abcb4-knockout) mice, a model of inflammation-media...

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Publicado en:Oncotarget
Autores principales: Stoyanov, Evgeniy, Ludwig, Guy, Mizrahi, Lina, Olam, Devorah, Schnitzer-Perlman, Temima, Tasika, Elena, Sass, Gabriele, Tiegs, Gisa, Jiang, Yong, Nie, Ting, Kohler, James, Schinazi, Raymond F., Vertino, Paula M., Cedar, Howard, Galun, Eithan, Goldenberg, Daniel
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484438/
https://ncbi.nlm.nih.gov/pubmed/25918251
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