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Tissue-specific roles of Fgfr2 in development of the external genitalia
Congenital anomalies frequently occur in organs that undergo tubulogenesis. Hypospadias is a urethral tube defect defined by mislocalized, oversized, or multiple openings of the penile urethra. Deletion of Fgfr2 or its ligand Fgf10 results in severe hypospadias in mice, in which the entire urethral...
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| Veröffentlicht in: | Development |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Company of Biologists
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4483768/ https://ncbi.nlm.nih.gov/pubmed/26081573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.119891 |
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