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Tissue-specific roles of Fgfr2 in development of the external genitalia

Congenital anomalies frequently occur in organs that undergo tubulogenesis. Hypospadias is a urethral tube defect defined by mislocalized, oversized, or multiple openings of the penile urethra. Deletion of Fgfr2 or its ligand Fgf10 results in severe hypospadias in mice, in which the entire urethral...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Gredler, Marissa L., Seifert, Ashley W., Cohn, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483768/
https://ncbi.nlm.nih.gov/pubmed/26081573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.119891
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