HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome

Steroid-sensitive nephrotic syndrome (SSNS) accounts for >80% of cases of nephrotic syndrome in childhood. However, the etiology and pathogenesis of SSNS remain obscure. Hypothesizing that coding variation may underlie SSNS risk, we conducted an exome array association study of SSNS. We enrolled...

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Pubblicato in:J Am Soc Nephrol
Autori principali: Gbadegesin, Rasheed A., Adeyemo, Adebowale, Webb, Nicholas J.A., Greenbaum, Larry A., Abeyagunawardena, Asiri, Thalgahagoda, Shenal, Kale, Arundhati, Gipson, Debbie, Srivastava, Tarak, Lin, Jen-Jar, Chand, Deepa, Hunley, Tracy E., Brophy, Patrick D., Bagga, Arvind, Sinha, Aditi, Rheault, Michelle N., Ghali, Joanna, Nicholls, Kathy, Abraham, Elizabeth, Janjua, Halima S., Omoloja, Abiodun, Barletta, Gina-Marie, Cai, Yi, Milford, David D., O'Brien, Catherine, Awan, Atif, Belostotsky, Vladimir, Smoyer, William E., Homstad, Alison, Hall, Gentzon, Wu, Guanghong, Nagaraj, Shashi, Wigfall, Delbert, Foreman, John, Winn, Michelle P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2015
Soggetti:
Clinical Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483579/
https://ncbi.nlm.nih.gov/pubmed/25349203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014030247
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