Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse

Mutations, duplication and triplication of α-synuclein genes are linked to familial Parkinson’s disease (PD), and aggregation of α-synuclein (α-syn) in Lewy bodies (LB) is involved in the pathogenesis of the disease. The targeted overexpression of α-syn in the substantia nigra (SN) mediated by viral...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Song, Lian-Kun, Ma, Kai-Li, Yuan, Yu-He, Mu, Zheng, Song, Xiu-Yun, Niu, Fei, Han, Ning, Chen, Nai-Hong
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483255/
https://ncbi.nlm.nih.gov/pubmed/26114655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131281
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