Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance

PICALM is highly validated genetic risk factor for Alzheimer’s disease (AD). Here, we report that PICALM reductions in AD and murine brain endothelium correlate with amyloid–β (Aβ) pathology and cognitive impairment. Moreover, Picalm deficiency diminishes Aβ clearance across the murine blood–brain b...

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Bibliografske podrobnosti
izdano v:Nat Neurosci
Main Authors: Zhao, Zhen, Sagare, Abhay P., Ma, Qingyi, Halliday, Matthew R., Kong, Pan, Kisler, Kassandra, Winkler, Ethan A., Ramanathan, Anita, Kanekiyo, Takahisa, Bu, Guojun, Owens, Nelly Chuqui, Rege, Sanket V., Si, Gabriel, Ahuja, Ashim, Zhu, Donghui, Miller, Carol A., Schneider, Julie A., Maeda, Manami, Maeda, Takahiro, Sugawara, Tohru, Ichida, Justin K., Zlokovic, Berislav V.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482781/
https://ncbi.nlm.nih.gov/pubmed/26005850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4025
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